Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration
نویسندگان
چکیده
منابع مشابه
Evaluation of administration of activated charcoal in the home.
OBJECTIVE Activated charcoal (AC) is recognized as the treatment of choice for gastrointestinal decontamination after many ingestions. AC use in the home has been limited by concerns that parents would not administer it properly and that children would refuse to take AC. Previous descriptions of home administration have reported mixed results. METHODS This was an 18-month consecutive case ser...
متن کاملEffect of charcoal-drug ratio on antidotal efficacy of oral activated charcoal in man.
The effect of charcoal-drug ratio on the antidotal efficacy of oral activated charcoal was studied in six healthy volunteers in a randomized cross-over study and compared with the adsorption capacity of activated charcoal in vitro. Aminosalicylic acid (PAS) 1 g and 5 g were ingested on an empty stomach in 30 ml of water. Immediately afterwards the subjects ingested 50 g of activated charcoal in...
متن کاملThe potential role of prehospital administration of activated charcoal.
OBJECTIVES Activated charcoal is now the mainstay of non-specific treatment for self poisoning in accident and emergency (A&E) departments and should be administered within one hour of ingestion of an overdose. This study aimed to investigate if compliance with treatment guidelines may be improved by the prehospital administration of activated charcoal. METHOD Ambulance report forms and case ...
متن کاملIndications for single-dose activated charcoal administration in acute overdose.
PURPOSE OF REVIEW Gastrointestinal decontamination in overdose patients remains a controversial problem in emergency medicine. There has been a significant decrease in the use of single-dose activated charcoal (SDAC) in recent years based on little new evidence and possibly because the overall mortality in overdose patients is low. RECENT FINDINGS Human volunteer studies suggest SDAC is effec...
متن کاملEffect of Activated Charcoal on Apixaban Pharmacokinetics in Healthy Subjects
BACKGROUND Activated charcoal is commonly used to manage overdose or accidental ingestion of medicines. This study evaluated the effect of activated charcoal on apixaban exposure in human subjects. METHODS This was an open-label, three-treatment, three-period, randomized, crossover study of single-dose apixaban (20 mg) administered alone and with activated charcoal given at 2 or 6 h post-dose...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1997
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1997.tb00134.x